Selank
Calms anxiety and lifts mood naturally
- Anxiety
- Stress Relief
- Depression
No evidence of tolerance or dependence development—a notable safety advantage over benzodiazepine anxiolytics May lower blood pressure; use caution in hypotensive individuals Potential anticoagulant effects; caution advised with concurrent blood-thinning medications
Mechanism of Action
Selank is a synthetic heptapeptide derived from the immunomodulatory peptide tuftsin. It acts primarily by inhibiting enkephalin-degrading enzymes (enkephalinases), particularly carboxypeptidases and dicarboxypeptidases, in blood plasma. This inhibition increases the half-life and availability of endogenous enkephalins, which are opioid peptides involved in mood regulation and stress response. Key Pathways: Enkephalinase inhibition (carboxypeptidases and dicarboxypeptidases), Endogenous opioid (enkephalin) system modulation, Stress-adaptive behavioral regulation By preserving enkephalins from rapid degradation, Selank may enhance the natural anxiolytic and mood-stabilizing effects of the endogenous opioid system. This mechanism correlates with observed reductions in anxiety-like behaviors in animal models, particularly in stress-sensitive phenotypes, and suggests potential benefits for stress adaptation and emotional regulation.
Common Dose Reference Ranges
Educational reference ranges only — discuss actual dosing with a qualified healthcare provider.
Full Selank protocols — frequency, timing, cycle length, reconstitution & research
- Fatigue or mild sedation
- Nasal irritation (intranasal administration)
- Headache
- Hypotension (decreased blood pressure)
- Increased cerebral blood flow
- Anticoagulant effects