Glutathione
Brightens skin and fights aging damage
- Antioxidant Support
- Liver Detoxification
- Immune Regulation
- Skin Brightening
Consult oncologist before use during cancer treatment - may interfere with oxidative stress-dependent therapies Limited human clinical trial data on long-term supplementation safety
Mechanism of Action
Glutathione (GSH) is a tripeptide thiol that serves as the body's primary intracellular antioxidant, directly neutralizing reactive oxygen species (ROS) and serving as a cofactor for glutathione peroxidase (GPX) enzymes that reduce hydrogen peroxide and lipid peroxides. It also conjugates with xenobiotics and toxins via glutathione-S-transferase (GST) enzymes, facilitating their elimination from the body. Key Pathways: Glutathione peroxidase (GPX) antioxidant system, Glutathione-S-transferase (GST) detoxification pathway, Nrf2/SLC7A11/GPX4 signaling axis, Cellular redox homeostasis maintenance By maintaining cellular redox balance, glutathione protects tissues from oxidative damage, supports liver detoxification of drugs and environmental toxins, and may influence immune cell function. The skin brightening effect attributed to glutathione is theorized to result from its inhibition of tyrosinase and interference with melanin synthesis pathways, though this mechanism is less well-established in rigorous human trials.
Common Dose Reference Ranges
Educational reference ranges only — discuss actual dosing with a qualified healthcare provider.
Full Glutathione protocols — frequency, timing, cycle length, reconstitution & research
- Gastrointestinal discomfort
- Potential interference with chemotherapy
- Allergic reactions
- Zinc depletion with chronic use
- Potential pro-oxidant effects in specific contexts