5-Amino-1MQ
Blocks fat storage, boosts energy metabolism
- Fat Loss
- Energy Production
- Anti-Aging
No human clinical trials exist — safety profile is unknown This is an experimental research compound, not an approved medication Long-term effects of NNMT inhibition in humans have not been studied Pregnant or breastfeeding individuals should avoid use due to complete lack of safety data
Mechanism of Action
5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that regulates cellular metabolism by consuming methyl donors and influencing NAD+ salvage pathways. By blocking NNMT activity, this compound is theorized to increase intracellular NAD+ levels and shift metabolic flux toward energy expenditure rather than fat storage. Key Pathways: NNMT inhibition, NAD+ salvage pathway modulation, SAM/SAH methylation cycle regulation, Adipocyte metabolic reprogramming The theoretical rationale suggests that NNMT inhibition could reduce fat accumulation and increase cellular energy production by restoring NAD+ availability and metabolic efficiency. In preclinical models, NNMT inhibition has been associated with reduced adiposity and improved metabolic parameters, which forms the basis for interest in fat loss and anti-aging applications.
Common Dose Reference Ranges
Educational reference ranges only — discuss actual dosing with a qualified healthcare provider.
Full 5-Amino-1MQ protocols — frequency, timing, cycle length, reconstitution & research
- Mild gastrointestinal discomfort
- Headache
- Unknown long-term effects
- Potential drug interactions